Chronic Thromboembolic Disease and Chronic Thromboembolic Pulmonary Hypertension

Clin Chest Med. 2021 Mar;42(1):81-90. doi: 10.1016/j.ccm.2020.11.014. Epub 2021 Jan 12.


Chronic thromboembolic pulmonary hypertension (CTEPH) and chronic thromboembolic pulmonary vascular disease (CTED) are rare manifestations of venous thromboembolism. Presumably, CTEPH and CTED are variants of the same pathophysiological mechanism. CTEPH and CTED can be near-cured by pulmonary endarterectomy, balloon pulmonary angioplasty, and medical treatment with Riociguat or subcutaneous treprostinil, which are the approved drugs.

Keywords: Acute pulmonary embolism; Chronic thromboembolic pulmonary hypertension; Chronic thromboembolic pulmonary vascular disease; Venous thromboembolism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chronic Disease / therapy
  • Humans
  • Hypertension, Pulmonary* / etiology
  • Hypertension, Pulmonary* / physiopathology
  • Hypertension, Pulmonary* / therapy
  • Pulmonary Embolism* / etiology
  • Pulmonary Embolism* / physiopathology
  • Pulmonary Embolism* / therapy
  • Venous Thromboembolism / complications*