P21-activated kinase 5 potentiates the chemoresistant phenotype of liver cancer

Signal Transduct Target Ther. 2021 Feb 5;6(1):47. doi: 10.1038/s41392-020-00409-y.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B / genetics
  • Adult
  • Aged
  • Animals
  • Apoptosis / drug effects
  • Carcinoma, Hepatocellular / drug therapy*
  • Carcinoma, Hepatocellular / genetics
  • Carcinoma, Hepatocellular / pathology
  • Cell Proliferation / drug effects
  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects
  • Drug Resistance, Neoplasm / genetics
  • Female
  • Gene Expression Regulation, Neoplastic / drug effects
  • Heterografts
  • Humans
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / genetics
  • Liver Neoplasms / pathology
  • Male
  • Mice
  • Middle Aged
  • p21-Activated Kinases / genetics*

Substances

  • ABCB1 protein, human
  • ATP Binding Cassette Transporter, Subfamily B
  • PAK5 protein, human
  • p21-Activated Kinases
  • Cisplatin