An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect

Lava Mohammad; Leen Doya; Razan Omran; Alexander Ibrahim; Zuheir Alshehabi; Ali Ibrahim

doi:10.1093/omcr/omaa126

An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect

Oxf Med Case Reports. 2021 Jan 23;2021(1):omaa126. doi: 10.1093/omcr/omaa126. eCollection 2021 Jan.

Authors

Lava Mohammad¹, Leen Doya¹, Razan Omran¹, Alexander Ibrahim², Zuheir Alshehabi³, Ali Ibrahim¹

Affiliations

¹ Department of Pediatrics, Tishreen University Hospital, Lattakia, Syria.
² Department of Internal Medicine, Tishreen University Hospital, Lattakia, Syria.
³ Department of Pathology, Tishreen University Hospital, Lattakia, Syria.

Abstract

Isoniazid (INH) is highly bactericidal against replicating tubercule bacilli and is involved in all antituberculous chemotherapeutic regimens. Several neurological adverse effects, following both therapeutic and overdose use of INH, have been reported in adults in the literature. Here, we present a case of a 5-year-old girl with intestinal Tuberculosis, who developed hemiclonic seizure as a side effect of INH therapeutic dose after 2 weeks of tuberculosis therapy.

Keywords: gastroenterology and hepatology; infectious diseases and tropical medicine; pediatrics.

Publication types

Case Reports