Whither Magnetic Hyperthermia? A Tentative Roadmap

Materials (Basel). 2021 Feb 3;14(4):706. doi: 10.3390/ma14040706.


The scientific community has made great efforts in advancing magnetic hyperthermia for the last two decades after going through a sizeable research lapse from its establishment. All the progress made in various topics ranging from nanoparticle synthesis to biocompatibilization and in vivo testing have been seeking to push the forefront towards some new clinical trials. As many, they did not go at the expected pace. Today, fruitful international cooperation and the wisdom gain after a careful analysis of the lessons learned from seminal clinical trials allow us to have a future with better guarantees for a more definitive takeoff of this genuine nanotherapy against cancer. Deliberately giving prominence to a number of critical aspects, this opinion review offers a blend of state-of-the-art hints and glimpses into the future of the therapy, considering the expected evolution of science and technology behind magnetic hyperthermia.

Keywords: cancer; hysteresis losses; magnetic hyperthermia; magnetic nanoparticles; magnetic particle imaging; nanoparticles synthesis; nanotoxicity; standardization; theranostics; thermometry.