Sexual excitation induces courtship ultrasonic vocalizations and cataplexy-like behavior in orexin neuron-ablated male mice

Commun Biol. 2021 Feb 5;4(1):165. doi: 10.1038/s42003-021-01696-z.

Abstract

Cataplexy is triggered by laughter in humans and palatable food in mice. To further evaluate mice's cataplexy, we examined courtship behavior in orexin neuron-ablated mice (ORX-AB), one of the animal models of narcolepsy/cataplexy. Wild-type female mice were placed into the home cage of male ORX-AB and cataplexy-like behavior was observed along with ultrasonic vocalizations (USVs), also known as the "love song". ORX-AB with a female encounter showed cataplexy-like behavior both during the dark and light periods, whereas ORX-AB with chocolate predominantly showed it during the dark period. During the light period observation, more than 85% of cataplexy-like bouts were preceded by USVs. A strong positive correlation was observed between the number of USVs and cataplexy-like bouts. Cataplexy-like behavior in narcoleptic mice is a good behavioral measure to study the brain mechanisms behind positive emotion because they can be induced by different kinds of positive stimuli, including chocolate and female courtship.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / physiology
  • Cataplexy / genetics
  • Cataplexy / pathology*
  • Cataplexy / physiopathology
  • Cataplexy / psychology
  • Courtship* / psychology
  • Genes, Transgenic, Suicide
  • Male
  • Mice
  • Mice, Transgenic
  • Narcolepsy / genetics
  • Narcolepsy / pathology
  • Narcolepsy / physiopathology
  • Narcolepsy / psychology
  • Neurons / metabolism
  • Neurons / pathology*
  • Orexins / deficiency
  • Orexins / genetics
  • Orexins / metabolism
  • Sexual Arousal*
  • Vocalization, Animal / physiology*

Substances

  • Orexins