Dosimetric Factors and Radiomics Features Within Different Regions of Interest in Planning CT Images for Improving the Prediction of Radiation Pneumonitis

Abstract

Purpose: This study aimed to establish machine learning models using dosimetric factors and radiomics features within 5 regions of interest (ROIs) in treatment planning computed tomography images to improve the prediction of symptomatic radiation pneumonitis (RP) (grade ≥2).

Methods and materials: This study retrospectively collected data on 79 patients with lung cancer (25 RP ≥2) who underwent chemoradiotherapy between 2015 and 2018. We defined 5 ROIs in planning computed tomography images: gross tumor volume (GTV), planning tumor volume (PTV), PTV-GTV, total lung (TL)-GTV, and TL-PTV. We calculated the mean dose, V5, V10, V20, and V30 within TL-GTV and TL-PTV and the mean dose within the other ROIs. A total of 1924 radiomics features were extracted from all 5 ROIs. We selected the best predictors for classifying 2 groups of patients using a sequential backward elimination support vector machine model. A permutation test was used to assess its statistical significance (P < .05).

Results: The best predictors for symptomatic RP were the combination of 11 radiomics features, 5 dosimetric factors, age, and T stage, achieving an area under the curve (AUC) of 0.94 (95% confidence interval [CI], 0.85-1) (accuracy, 90%; sensitivity, 80% [95% CI, 44%-96%]; specificity, 95% [95% CI, 73%-100%]; P = 8 × 10^-4). The clinical characteristics, dosimetric factors, and their combination showed limited predictive power (accuracy, 63.3%, 70%, and 70%; AUC [95% CI]: 0.73 [0.54-0.92], 0.53 [0.31-0.75], and 0.72 [0.51-0.92], respectively). The radiomics features of PTV-GTV and TL-PTV outperformed those of the other ROIs (accuracy, 76.7% and 76.7%; AUC [95% CI]: 0.82 [0.65-0.99] and 0.80 [0.59-1], respectively).

Conclusions: Combining dosimetric factors and radiomics features within different ROIs can improve the prediction of symptomatic RP. Our results can help physicians adjust the radiation dose distribution of the dose-sensitive lungs and target volumes based on personalized RP estimates.