Aberrant monocyte subsets in patients with Behçet's disease

Clin Immunol. 2021 Apr;225:108683. doi: 10.1016/j.clim.2021.108683. Epub 2021 Feb 5.

Abstract

Monocytes are a versatile and dynamic population, but its implication in Behçet's Disease (BD) remains elusive. We investigated the proportion, phenotypical and functional alterations in classical monocytes (CM), intermediate monocytes (IM) and non-classical monocytes (NCM) subsets in BD. A higher IM and lower NCM population in BD patients were noted, closely correlated with disease activity, and rescued after treatment. CD11b and CD64 expression on CM, IM and NCM in BD were enhanced. BD CM promoted TNF-a and IL-6 production and facilitated Th1 differentiation. BD IM promoted IL-6 production. We further demonstrated a higher level of phosphorylated p65 (p-p65) in BD CM and increased p-p65 and p-p38 in BD IM. Our data highlighted the aberrant populations of IM and CM in BD, potentially implicated in BD' pathogenesis.

Keywords: Behçet's disease; Monocyte subsets.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Behcet Syndrome / immunology*
  • CD11b Antigen / metabolism
  • Cell Differentiation
  • Cytokines / metabolism
  • Disease Progression
  • Female
  • Humans
  • Immunophenotyping
  • Inflammation Mediators / metabolism
  • Male
  • Middle Aged
  • Monocytes / immunology*
  • Phosphorylation
  • Receptors, IgG / metabolism
  • Signal Transduction
  • Th1 Cells / immunology*

Substances

  • CD11b Antigen
  • Cytokines
  • Inflammation Mediators
  • Receptors, IgG