Skeletal muscle mitochondria in health and disease

Abstract

Mitochondrial activity warrants energy supply to oxidative myofibres to sustain endurance workload. The maintenance of mitochondrial homeostasis is ensured by the control of fission and fusion processes and by the mitophagic removal of aberrant organelles. Many diseases are due to or characterized by dysfunctional mitochondria, and altered mitochondrial dynamics or turnover trigger myopathy per se. In this review, we will tackle the role of mitochondrial dynamics, turnover and metabolism in skeletal muscle, both in health and disease.

Keywords: Fusion and fission machinery; Mitochondrial calcium uptake; Mitochondrial myopathies; Mitophagy; Skeletal muscle.