Hippocampal beta oscillations predict mouse object-location associative memory performance

Hippocampus. 2021 May;31(5):503-511. doi: 10.1002/hipo.23311. Epub 2021 Feb 8.

Abstract

Memorizing the locations of environmental cues is crucial for survival and depends on the hippocampus. We recorded local field potentials (LFPs) from the hippocampus of freely moving mice during an object location task. The power of beta-band (23-30 Hz) oscillations increased immediately before approaching objects in a memory-encoding phase. The exploration-induced beta oscillations gradually decreased during the memory-encoding session. Mice that exhibited stronger beta oscillation power exhibited better performance in the subsequent memory-retrieval test. These results suggest that beta oscillations in the hippocampal CA1 region are involved in the memory encoding of object-location associations.

Keywords: hippocampus; local field potential; object location memory; slow gamma.