Liver aspartate aminotransferase activity as a power function of body weight

Biochem Med Metab Biol. 1988 Feb;39(1):121-5. doi: 10.1016/0885-4505(88)90067-9.

Abstract

Total liver enzyme activity (E) for aspartate aminotransferase (ASAT; EC 2.6.1.1) per gram body weight (W) decreases in six species as body weight increases from mice to cattle according to the equation E/W 0.85 = c, where c is a constant. The 0.85 power of body weight thereby provides a reference standard for the direct arithmetic comparison of liver ASAT activities in six species with different body weights. The use of W 0.85 should provide a tool in clinical studies in which data from experimental animals must be related to humans, e.g., in establishing the relationship between drug dosage (or toxicity) and body weight.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Animals
  • Aspartate Aminotransferases / metabolism*
  • Body Weight*
  • Cattle
  • Dogs
  • Female
  • Humans
  • Liver / enzymology*
  • Male
  • Mice
  • Rabbits
  • Rats
  • Species Specificity

Substances

  • Aspartate Aminotransferases