Chromatin openness requires continuous SWI/SNF activity

Nat Genet. 2021 Mar;53(3):263-264. doi: 10.1038/s41588-021-00781-7.


Chromatin structure and specifically sites of open or accessible chromatin regulate transcription factor binding to determine cell type-specific gene expression. Two new studies find that there is a constant requirement for SWI/SNF complex remodeling to maintain open chromatin using chemical and genetic methods that acutely inhibit or degrade the BRG1/BRM ATPase subunits, leading to loss in transcription factor binding and altered gene expression.

Publication types

  • Comment

MeSH terms

  • Animals
  • Chromatin* / genetics
  • Chromosomal Proteins, Non-Histone / genetics
  • Transcription Factors* / genetics


  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Transcription Factors