Efficient one-pot synthesis of substituted diphenyl 1, 3-thiazole through multicomponent reaction by using green and efficient Iron-catalyst via Cross-Dehydrogenative Coupling(CDC)

Manjit Singh; Vijay B Yadav; Mohd Danish Ansari; Manisha Malviya; I R Siddiqui

doi:10.1007/s11030-021-10191-w

Efficient one-pot synthesis of substituted diphenyl 1, 3-thiazole through multicomponent reaction by using green and efficient Iron-catalyst via Cross-Dehydrogenative Coupling(CDC)

Mol Divers. 2022 Apr;26(2):843-848. doi: 10.1007/s11030-021-10191-w. Epub 2021 Feb 8.

Authors

Manjit Singh¹, Vijay B Yadav², Mohd Danish Ansari², Manisha Malviya³, I R Siddiqui⁴

Affiliations

¹ Department of Chemistry IIT BHU, Varanasi, India.
² Laboratory of Green Synthesis, Department of Chemistry, University of Allahabad, Prayagraj, 211001, India.
³ Department of Chemistry IIT BHU, Varanasi, India. manisha.apc@iitbhu.ac.in.
⁴ Laboratory of Green Synthesis, Department of Chemistry, University of Allahabad, Prayagraj, 211001, India. dr.irsiddiqui@gamil.com.

PMID: 33559099
DOI: 10.1007/s11030-021-10191-w

Abstract

A clean and efficient, multi-component strategy for the synthesis of biologically important trisubstituted thiazole via the reaction of readily available barbituric acid, acetophenone, and aryl thioamides is reported in the presence of FeCl₃.6H₂O / O₂(Air) in DMF solvent. The advantages of the present methodology include a one-pot reaction, environment-friendly approach, cost-effectiveness, broad substrate scope, operational simplicity, short reaction time, easy workup procedure, and high yields.

Keywords: Acetophenone; Barbituric acid; Eco-friendly reaction condition; Green synthesis; Thiazole; one pot reaction.

MeSH terms

Biphenyl Compounds
Catalysis
Iron*
Thiazoles*

Substances

Biphenyl Compounds
Iron
Thiazoles
biphenyl