Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations

doi:10.1002/nbm.4484

. 2021 May;34(5):e4484.

doi: 10.1002/nbm.4484. Epub 2021 Feb 9.

Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations

Alexander Lin¹, Ovidiu Andronesi², Wolfgang Bogner³, In-Young Choi⁴, Eduardo Coello¹, Cristina Cudalbu⁵, Christoph Juchem⁶, Graham J Kemp⁷, Roland Kreis⁸, Martin Krššák⁹, Phil Lee¹⁰, Andrew A Maudsley¹¹, Martin Meyerspeer¹², Vladamir Mlynarik¹³, Jamie Near¹⁴, Gülin Öz¹⁵, Aimie L Peek¹⁶, Nicolaas A Puts¹⁷, Eva-Maria Ratai¹⁸, Ivan Tkáč¹⁶, Paul G Mullins¹⁹; Experts' Working Group on Reporting Standards for MR Spectroscopy

Affiliations

¹ Center for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
² Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
³ High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
⁴ Department of Neurology, Hoglund Biomedical Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
⁵ Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁶ Departments of Biomedical Engineering and Radiology, Columbia University, New York, New York, USA.
⁷ Department of Musculoskeletal and Ageing Science and Liverpool Magnetic Resonance Imaging Centre (LiMRIC), University of Liverpool, Liverpool, UK.
⁸ Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland.
⁹ Department of Medicine III and Department of Biomedical Imaging and Image guided Therapy, Medical University of Vienna, Vienna, Austria.
¹⁰ Department of Radiology, Hoglund Biomedical Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
¹¹ Department of Radiology, University of Miami, Coral Gables, Florida, USA.
¹² High Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
¹³ Magnetic Resonance Centre of Excellence. Medical University of Vienna, Vienna, Austria.
¹⁴ Brain Imaging Centre, Douglas Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
¹⁵ Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
¹⁶ Faculty of Health Sciences, University of Sydney, Sydney, Australia.
¹⁷ Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
¹⁸ A.A. Martinos Center for Biomedical Imaging, Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
¹⁹ Bangor Imaging Unit, School of Psychology, Bangor University, Bangor, Gwynedd, UK.

PMID: 33559967
PMCID: PMC8647919
DOI: 10.1002/nbm.4484

Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations

Alexander Lin et al. NMR Biomed. 2021 May.

. 2021 May;34(5):e4484.

doi: 10.1002/nbm.4484. Epub 2021 Feb 9.

Authors

Affiliations

¹ Center for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
² Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
³ High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
⁴ Department of Neurology, Hoglund Biomedical Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
⁵ Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁶ Departments of Biomedical Engineering and Radiology, Columbia University, New York, New York, USA.
⁷ Department of Musculoskeletal and Ageing Science and Liverpool Magnetic Resonance Imaging Centre (LiMRIC), University of Liverpool, Liverpool, UK.
⁸ Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland.
⁹ Department of Medicine III and Department of Biomedical Imaging and Image guided Therapy, Medical University of Vienna, Vienna, Austria.
¹⁰ Department of Radiology, Hoglund Biomedical Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
¹¹ Department of Radiology, University of Miami, Coral Gables, Florida, USA.
¹² High Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
¹³ Magnetic Resonance Centre of Excellence. Medical University of Vienna, Vienna, Austria.
¹⁴ Brain Imaging Centre, Douglas Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
¹⁵ Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
¹⁶ Faculty of Health Sciences, University of Sydney, Sydney, Australia.
¹⁷ Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
¹⁸ A.A. Martinos Center for Biomedical Imaging, Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
¹⁹ Bangor Imaging Unit, School of Psychology, Bangor University, Bangor, Gwynedd, UK.

PMID: 33559967
PMCID: PMC8647919
DOI: 10.1002/nbm.4484

Abstract

The translation of MRS to clinical practice has been impeded by the lack of technical standardization. There are multiple methods of acquisition, post-processing, and analysis whose details greatly impact the interpretation of the results. These details are often not fully reported, making it difficult to assess MRS studies on a standardized basis. This hampers the reviewing of manuscripts, limits the reproducibility of study results, and complicates meta-analysis of the literature. In this paper a consensus group of MRS experts provides minimum guidelines for the reporting of MRS methods and results, including the standardized description of MRS hardware, data acquisition, analysis, and quality assessment. This consensus statement describes each of these requirements in detail and includes a checklist to assist authors and journal reviewers and to provide a practical way for journal editors to ensure that MRS studies are reported in full.

Keywords: MR spectroscopy (MRS) and spectroscopic imaging (MRSI) methods; reporting guidelines.

PubMed Disclaimer

Figures

**FIGURE 1**
Representative spectrum and voxel location. Representative PRESS spectrum from the posterior cingulate acquired on a 3 T Philips Ingenia. In this figure the raw data from one participant are shown; however, mean data with SDs, multiple data sets, and fitted data may also be shown, as long as the raw data are presented in a fashion that allows an assessment of data quality. The chemical shift axis is labeled in ppm units. Data were collected in accordance with the WMA Declaration of Helsinki

See this image and copyright information in PMC

Cited by

Retrospective analysis of Braak stage- and APOE4 allele-dependent associations between MR spectroscopy and markers of tau and neurodegeneration in cognitively unimpaired elderly.
Chen AM, Gajdošík M, Ahmed W, Ahn S, Babb JS, Blessing EM, Boutajangout A, de Leon MJ, Debure L, Gaggi N, Gajdošík M, George A, Ghuman M, Glodzik L, Harvey P, Juchem C, Marsh K, Peralta R, Rusinek H, Sheriff S, Vedvyas A, Wisniewski T, Zheng H, Osorio R, Kirov II. Chen AM, et al. Neuroimage. 2024 Aug 15;297:120742. doi: 10.1016/j.neuroimage.2024.120742. Epub 2024 Jul 18. Neuroimage. 2024. PMID: 39029606 Free PMC article.
Molecular MRI-Based Monitoring of Cancer Immunotherapy Treatment Response.
Vladimirov N, Perlman O. Vladimirov N, et al. Int J Mol Sci. 2023 Feb 5;24(4):3151. doi: 10.3390/ijms24043151. Int J Mol Sci. 2023. PMID: 36834563 Free PMC article. Review.
Quantifying GABA in Addiction: A Review of Proton Magnetic Resonance Spectroscopy Studies.
Shyu C, Chavez S, Boileau I, Le Foll B. Shyu C, et al. Brain Sci. 2022 Jul 13;12(7):918. doi: 10.3390/brainsci12070918. Brain Sci. 2022. PMID: 35884725 Free PMC article. Review.
Mapping intracellular NAD content in entire human brain using phosphorus-31 MR spectroscopic imaging at 7 Tesla.
Guo R, Yang S, Wiesner HM, Li Y, Zhao Y, Liang ZP, Chen W, Zhu XH. Guo R, et al. Front Neurosci. 2024 Jun 7;18:1389111. doi: 10.3389/fnins.2024.1389111. eCollection 2024. Front Neurosci. 2024. PMID: 38911598 Free PMC article.
The developmental trajectory of 1H-MRS brain metabolites from childhood to adulthood.
Thomson AR, Hwa H, Pasanta D, Hopwood B, Powell HJ, Lawrence R, Tabuenca ZG, Arichi T, Edden RAE, Chai X, Puts NA. Thomson AR, et al. Cereb Cortex. 2024 Mar 1;34(3):bhae046. doi: 10.1093/cercor/bhae046. Cereb Cortex. 2024. PMID: 38430105 Free PMC article.

See all "Cited by" articles

References

1. Oz G, Alger JR, Barker PB, et al. Clinical proton MR spectroscopy in central nervous system disorders. Radiology. 2014;270(3):658‐679. 10.1148/radiol.13130531 - DOI - PMC - PubMed
1. Wilson M, Andronesi O, Barker PB, et al. Methodological consensus on clinical proton MRS of the brain: review and recommendations. Magn Reson Med. 2019;82(2):527‐550. 10.1002/mrm.27742 - DOI - PMC - PubMed
1. Landis SC, Amara SG, Asadullah K, et al. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012;490(7419):187‐191. 10.1038/nature11556 - DOI - PMC - PubMed
1. Cudalbu C, Taylor‐Robinson SD. Brain edema in chronic hepatic encephalopathy. J Clin Exp Hepatol. 2019;9(3):362‐382. 10.1016/j.jceh.2019.02.003 - DOI - PMC - PubMed
1. Peek AL, Rebbeck T, Puts NAJ, Watson J, Aguila ME, Leaver AM. Brain GABA and glutamate levels across pain conditions: a systematic literature review and meta‐analysis of 1H‐MRS studies using the MRS‐Q quality assessment tool. NeuroImage. 2020;210:116532. 10.1016/j.neuroimage.2020.116532 - DOI - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

[1] Oz G, Alger JR, Barker PB, et al. Clinical proton MR spectroscopy in central nervous system disorders. Radiology. 2014;270(3):658‐679. 10.1148/radiol.13130531 - DOI - PMC - PubMed

[2] Oz G, Alger JR, Barker PB, et al. Clinical proton MR spectroscopy in central nervous system disorders. Radiology. 2014;270(3):658‐679. 10.1148/radiol.13130531 - DOI - PMC - PubMed

[3] Wilson M, Andronesi O, Barker PB, et al. Methodological consensus on clinical proton MRS of the brain: review and recommendations. Magn Reson Med. 2019;82(2):527‐550. 10.1002/mrm.27742 - DOI - PMC - PubMed

[4] Wilson M, Andronesi O, Barker PB, et al. Methodological consensus on clinical proton MRS of the brain: review and recommendations. Magn Reson Med. 2019;82(2):527‐550. 10.1002/mrm.27742 - DOI - PMC - PubMed

[5] Landis SC, Amara SG, Asadullah K, et al. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012;490(7419):187‐191. 10.1038/nature11556 - DOI - PMC - PubMed

[6] Landis SC, Amara SG, Asadullah K, et al. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012;490(7419):187‐191. 10.1038/nature11556 - DOI - PMC - PubMed

[7] Cudalbu C, Taylor‐Robinson SD. Brain edema in chronic hepatic encephalopathy. J Clin Exp Hepatol. 2019;9(3):362‐382. 10.1016/j.jceh.2019.02.003 - DOI - PMC - PubMed

[8] Cudalbu C, Taylor‐Robinson SD. Brain edema in chronic hepatic encephalopathy. J Clin Exp Hepatol. 2019;9(3):362‐382. 10.1016/j.jceh.2019.02.003 - DOI - PMC - PubMed

[9] Peek AL, Rebbeck T, Puts NAJ, Watson J, Aguila ME, Leaver AM. Brain GABA and glutamate levels across pain conditions: a systematic literature review and meta‐analysis of 1H‐MRS studies using the MRS‐Q quality assessment tool. NeuroImage. 2020;210:116532. 10.1016/j.neuroimage.2020.116532 - DOI - PubMed

[10] Peek AL, Rebbeck T, Puts NAJ, Watson J, Aguila ME, Leaver AM. Brain GABA and glutamate levels across pain conditions: a systematic literature review and meta‐analysis of 1H‐MRS studies using the MRS‐Q quality assessment tool. NeuroImage. 2020;210:116532. 10.1016/j.neuroimage.2020.116532 - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations

Affiliations

Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations

Authors

Affiliations

Abstract

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources