Targeting the Microbiome to Overcome Resistance

Cancer Cell. 2021 Feb 8;39(2):151-153. doi: 10.1016/j.ccell.2021.01.016.


Immune checkpoint inhibition has revolutionized the treatment of many cancers, including melanoma. However, primary and acquired resistance remain key challenges for the field. Promising results from a phase I clinical trial recently published in Science highlight the potential of modulating the microbiome via fecal transplant to overcome resistance to immunotherapy.