Bio-inspired nanomaterials as novel options for the treatment of cardiovascular disease

Drug Discov Today. 2021 May;26(5):1200-1211. doi: 10.1016/j.drudis.2021.01.035. Epub 2021 Feb 6.


Cardiovascular disease (CVD) and its sequelae have long been the leading causes of death and disability in the developed world. Although mortality associated with CVD has been decreasing, due in large part to novel therapeutic options, the rate of decrease has flattened. Thus, there is a great need to investigate alternate therapeutic strategies that can increase efficacy while decreasing adverse effects. Nanomaterials have been widely investigated and have emerged as promising tools for both therapeutic and diagnostic purposes in oncology; however, the potential of nanomaterials has not been extensively explored for cardiovascular medicine. In this review, we focus on recent developments in the field of nanomedicines targeted for CVDs, with a special emphasis on cell membrane-coated nanoparticles (NPs) and their applications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / drug therapy*
  • Cell Membrane / chemistry
  • Drug Delivery Systems*
  • Humans
  • Nanomedicine / methods
  • Nanoparticles*
  • Nanostructures