Evidence for in situ amplification of a germ line homogeneously staining region in the mouse

Cytogenet Cell Genet. 1988;47(1-2):84-5. doi: 10.1159/000132512.


A cloned DNA sequence that is specific for a germ line homogeneously staining region (HSR) on chromosome 1 of the mouse was found to be homologous to a single copy sequence in non-HSR mice. By in situ hybridization, the sequence in non-HSR mice was localized to approximately the same site as the insertion site of the HSR on chromosome 1 of HSR mice, indicating in situ amplification of the HSR.

MeSH terms

  • Animals
  • Chromosome Mapping
  • DNA / genetics
  • Gene Amplification*
  • Mice / genetics*
  • Nucleic Acid Hybridization


  • DNA