DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury

Redox Biol. 2021 May:41:101884. doi: 10.1016/j.redox.2021.101884. Epub 2021 Jan 30.


DJ-1 is a multifaceted protein with pleiotropic functions that has been implicated in multiple diseases, ranging from neurodegeneration to cancer and ischemia-reperfusion injury. Ischemia is a complex pathological state arising when tissues and organs do not receive adequate levels of oxygen and nutrients. When the blood flow is restored, significant damage occurs over and above that of ischemia alone and is termed ischemia-reperfusion injury. Despite great efforts in the scientific community to ameliorate this pathology, its complex nature has rendered it challenging to obtain satisfactory treatments that translate to the clinic. In this review, we will describe the recent findings on the participation of the protein DJ-1 in the pathophysiology of ischemia-reperfusion injury, firstly introducing the features and functions of DJ-1 and, successively highlighting the therapeutic potential of the protein.

Keywords: DJ-1; Glucose homeostasis; Ionic balance; Ischemia-reperfusion injury; Mitochondrial homeostasis; Reactive oxygen species.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Ischemia
  • Protein Deglycase DJ-1
  • Reactive Oxygen Species
  • Reperfusion Injury*


  • Reactive Oxygen Species
  • Protein Deglycase DJ-1