[Constructive Understanding of Multi-scale Dynamism of Neuropsychiatric Disorders]

Brain Nerve. 2021 Feb;73(2):171-178. doi: 10.11477/mf.1416201729.
[Article in Japanese]

Abstract

Although synaptic abnormalities are implicated in the pathophysiology of schizophrenia, it remains unclear whether the synaptic pathology is a casual mechanism that controls the behaviors, or whether it is merely a secondary consequence of the disorder. Chaotic behavior and fluctuations in the pathophysiology of schizophrenia also make it challenging to gain a better understanding of the disorder. In this study, we focused on the disorders in a constructive and multi-scale manner, we attempt to elucidate the causal relationships across the hierarchy between schizophrenia-related genes and disease-related behaviors.

MeSH terms

  • Humans
  • Schizophrenia* / genetics