Preliminary Validation of the Global Neuropsychological Assessment in Alzheimer's Disease and Healthy Volunteers

Assessment. 2022 Jun;29(4):817-825. doi: 10.1177/1073191121991221. Epub 2021 Feb 9.


Methods: We administered the Global Neuropsychological Assessment (GNA), an abbreviated cognitive battery, to 105 adults aged 73.0 ± 7.1 years, including 28 with probable Alzheimer's disease, 9 with amnestic mild cognitive impairment, and 68 healthy controls. We examined group differences in baseline performance, test-retest reliability, and correlations with other conventional tests.

Results: Healthy adults outperformed patients on all five GNA subtests. Test-retest intraclass correlation coefficients were significant for all GNA subtests. Among patients with healthy controls, GNA Story Memory correlated best with Wechsler Memory Scale-Revised (WMS-R) Logical Memory for learning and delayed recall, GNA Digit Span correlated most highly with the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III) Digit Span, GNA Perceptual Comparison correlated most highly with the Trail Making Test, and GNA Animal Naming correlated most highly with Supermarket Item Naming.

Conclusions: Preliminary findings suggest that the GNA shows good test-retest validity, clear convergent and discriminant construct validity, and excellent diagnostic criterion validity for dementia and mild cognitive impairment in an American sample.

Keywords: Alzheimer’s disease; GNA; amnestic MCI; cognitive assessment; neuropsychology.

MeSH terms

  • Alzheimer Disease* / diagnosis
  • Cognitive Dysfunction* / diagnosis
  • Healthy Volunteers
  • Humans
  • Neuropsychological Tests
  • Reproducibility of Results