(-)- trans9-Tetrahydrocannabiphorol Content of Cannabis sativa Inflorescence from Various Chemotypes

J Nat Prod. 2021 Feb 26;84(2):531-536. doi: 10.1021/acs.jnatprod.0c01034. Epub 2021 Feb 10.

Abstract

The (-)-trans9-tetrahydrocannabiphorol (Δ9-THCP, 1) content of the inflorescence from six Cannabis sativa chemotypes, including 14 plants of distinct genotypes, and two extracts was determined quantitatively via high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). This represents the first comprehensive quantitative screening for 1 from various C. sativa chemotypes. Compound 1 was detected in all 13 inflorescence samples originating from "(-)-trans9-tetrahydrocannabinol (Δ9-THC, 2) dominant" C. sativa chemotypes, but was not detected in a "cannabidiol (CBD, 3) dominant" chemotype. The inflorescence content of 1 ranged approximately from 0.0023% to 0.0136% (w/w). Comprehensive inflorescence sampling was performed for each specimen investigated. A trend between inflorescence cannabinoid potency and the location of which the inflorescence was sampled on the C. sativa plant was observed for the three cannabinoids tested (1-3). The preliminary results obtained indicate Δ9-THCP (1) may have a higher degree of prevalence in C. sativa inflorescence than previously estimated.

MeSH terms

  • Cannabinoids / analysis*
  • Cannabis / chemistry*
  • Genotype
  • Inflorescence / chemistry*
  • Molecular Structure
  • Plant Extracts / chemistry

Substances

  • Cannabinoids
  • Plant Extracts