Human lung macrophages: roll up for the MISTRG tour

Immunity. 2021 Feb 9;54(2):194-196. doi: 10.1016/j.immuni.2021.01.006.


The human lung harbors diverse macrophages that provide barrier immunity and maintain homeostasis, but their precursors are unclear. In this issue of Immunity, Evren et al. use a humanized mouse model to discern that classical monocytes give rise to alveolar and interstitial macrophages, whereas non-classical monocytes contribute to pulmonary intravascular macrophages.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Lung*
  • Macrophages
  • Macrophages, Alveolar*
  • Mice
  • Monocytes