A case of Anti-LGi1 antibody positive autoimmune epilepsy following deep brain stimulator implantation for essential tremor

J Neuroimmunol. 2021 Apr 15;353:577503. doi: 10.1016/j.jneuroim.2021.577503. Epub 2021 Jan 30.


We describe a 59-year-old male who developed faciobrachial dystonic seizures and serum Anti-LGi1 antibody positivity 5 weeks after subthalamic deep brain stimulation (DBS) implantation for essential tremor. Brain MRI prior to implantation was normal. Electroencephalogram was normal. A lung lesion with low PET avidity was identified and biopsied; histology was non-diagnostic. Treatment response to immunoglobulin was observed. Seizures after DBS implantation are rare, and to our knowledge not described in association with anti-LGi1 antibodies.

Keywords: anti-LGi1 antibodies; anti-neuronal antibodies; autoimmune epilepsy; deep brain stimulation.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / immunology
  • Autoantigens / immunology
  • Autoimmune Diseases / drug therapy
  • Autoimmune Diseases / etiology*
  • Deep Brain Stimulation / adverse effects*
  • Electrodes, Implanted / adverse effects
  • Epilepsy / drug therapy
  • Epilepsy / etiology*
  • Essential Tremor / therapy*
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Immunologic Factors / therapeutic use
  • Intracellular Signaling Peptides and Proteins / immunology*
  • Male
  • Middle Aged


  • Autoantibodies
  • Autoantigens
  • Immunoglobulins, Intravenous
  • Immunologic Factors
  • Intracellular Signaling Peptides and Proteins
  • LGI1 protein, human