Tryptophan metabolites get the gut moving

Cell Host Microbe. 2021 Feb 10;29(2):145-147. doi: 10.1016/j.chom.2021.01.009.


How gut microbes can regulate the enteric nervous system and gut-brain communications is a field of intense research. In this issue of Cell Host & Microbe, Ye et al. demonstrate that bacteria can control intestinal motility and vagal neuronal activation via tryptophan catabolites through the receptor TrpA1 of enteroendocrine cells.

Publication types

  • Comment

MeSH terms

  • Bacteria
  • Enteric Nervous System*
  • Enteroendocrine Cells
  • Gastrointestinal Microbiome*
  • Tryptophan


  • Tryptophan