Comment on "Structural evidence for a dynamic metallocofactor during N2 reduction by Mo-nitrogenase"

Science. 2021 Feb 12;371(6530):eabe5481. doi: 10.1126/science.abe5481.


Kang et al (Reports, 19 June 2020, p. 1381) report a structure of the nitrogenase MoFe protein that is interpreted to indicate binding of N2 or an N2-derived species to the active-site FeMo cofactor. Independent refinement of the structure and consideration of biochemical evidence do not support this claim.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Comment

MeSH terms

  • Azotobacter vinelandii*
  • Catalytic Domain
  • Molybdoferredoxin*
  • Nitrogenase / metabolism


  • Molybdoferredoxin
  • Nitrogenase