Multiple sclerosis is a chronic central nervous system infection by a spirochetal agent

Med Hypotheses. 1988 Feb;25(2):89-92. doi: 10.1016/0306-9877(88)90023-0.


Multiple Sclerosis (MS) is a chronic central nervous system (CNS) infection similar to Lyme Disease or Neurosyphilis in its latency period, pathogenesis, symptoms, histopathology and chronic CNS involvement. It does not have as yet a fully identified spirochetal etiological agent. Much research and clinical support for this hypothesis was published before 1954 and is based on silver staining of neural lesions, animal isolation of the etiologic agent and the characteristic symptoms and pathogenesis of the disease. If this hypothesis is correct, the disease should be treatable with antibacterial agents that penetrate the CNS (such as high dose antibiotics), diagnosible by specific immunological tests, and preventable by early treatment or by the use of vaccines in high risk populations.

MeSH terms

  • Animals
  • Humans
  • Multiple Sclerosis / etiology*
  • Spirochaetales Infections*