A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe

Nature. 1988 Apr 7;332(6164):509-14. doi: 10.1038/332509a0.


In fission yeast, meiosis is initiated by transcriptional activation of the mei3+ gene, under the combined influence of the four mating-type genes. The product of the mei3+ gene acts as a critical meiotic inducer by binding non-covalently to a newly identified protein kinase encoded by the ran1+ gene and inhibiting its enzymatic activity. Inactivation of the ran1+ protein kinase is both necessary and sufficient to divert a vegetative cell from mitotic division to meiotic differentiation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Fungal Proteins / antagonists & inhibitors*
  • Fungal Proteins / genetics
  • Fungal Proteins / physiology*
  • Genes, Fungal
  • Genes, Mating Type, Fungal
  • Mating Factor
  • Meiosis*
  • Peptides / physiology
  • Phosphorylation
  • Protein Kinase Inhibitors*
  • Protein Kinases / genetics
  • Protein Kinases / physiology
  • Recombinant Fusion Proteins / metabolism
  • Saccharomycetales / physiology*
  • Schizosaccharomyces / genetics
  • Schizosaccharomyces / physiology*


  • Fungal Proteins
  • Peptides
  • Protein Kinase Inhibitors
  • Recombinant Fusion Proteins
  • Mating Factor
  • Protein Kinases