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. 2021 Jun 1;78(6):760-762.
doi: 10.1001/jamaneurol.2021.0225.

Assessing Brain Capillaries in Coronavirus Disease 2019

David W Nauen  1 , Jody E Hooper  1 , C Matthew Stewart  2 , Isaac H Solomon  3
Affiliations

Assessing Brain Capillaries in Coronavirus Disease 2019

David W Nauen et al. JAMA Neurol. .

Abstract

This case series analyzes brains from autopsies of patients who died of coronavirus disease 2019 as confirmed by nucleic acid test and with severe pulmonary pathology.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Nauen reports grant support from the National Institutes of Health/National Institute of Neurological Disorders and Stroke during the conduct of the study. Dr Hooper reports grants from the National Institutes of Health/National Cancer Institute during the conduct of the study. Dr Solomon reports grants from National Institutes of Health/National Institute of Neurological Disorders and Stroke during the conduct of the study and authorship payments and royalties from Elsevier outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Megakaryocytes in Cortical Capillaries of Patients With Coronavirus Disease 2019
A, Examples of megakaryocytes in cortical capillaries from affected cases (hematoxylin-eosin). B, CD61 antibody confirms megakaryocyte identity (cellmarque 161M-18; clone Ms/2f2). C, CD42b antibody further confirms megakaryocyte identity (abcam Ab183345; clone SP219). D, Platelet clusters also stained with CD61 antibody and are readily distinguished from megakaryocytes morphologically. The section thickness was 10 μm. Original magnification was ×1000 except for panel C (original magnification ×600).
See this image and copyright information in PMC

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