Upper Airway Assessment and Responses During Mechanically Assisted Cough

Respir Care. 2021 Jul;66(7):1196-1213. doi: 10.4187/respcare.08960. Epub 2021 Feb 12.


When the ability to cough is impaired, secretion clearance may be assisted and augmented with mechanical insufflation-exsufflation (MI-E). In some individuals, the efficacy of MI-E may be hampered by counterproductive upper airway reactions, where the airways close in response to positive pressures. To fully utilize the therapeutic potential inherent in the MI-E technology, we need a better understanding of the pathophysiology behind these untoward reactions. There is increasing interest in monitoring and measuring upper airway responses to MI-E and how such information can be used to optimize MI-E settings. The purpose of this narrative review is to increase the theoretical understanding of the larynx as a respiratory organ, summarize the current literature in the area, and provide insight into how this knowledge can affect current clinical practice.

Keywords: assessment; bulbar paresis; cough augmentation; laryngoscopy; larynx; mechanical insufflation-exsufflation; motor neuron disease; neuromuscular disease; upper airways.

Publication types

  • Review

MeSH terms

  • Cough / etiology
  • Humans
  • Insufflation*
  • Larynx*
  • Neuromuscular Diseases*
  • Respiration, Artificial