Clinical and genetic characteristics of children with acute lymphoblastic leukemia and Li-Fraumeni syndrome

Greta Winter; Renate Kirschner-Schwabe; Stefanie Groeneveld-Krentz; Gabriele Escherich; Anja Möricke; Arend von Stackelberg; Martin Stanulla; Simon Bailey; Lisa Richter; Doris Steinemann; Tim Ripperger; Adela Escudero; Roula Farah; Olli Lohi; Karin Wadt; Marjolijn Jongmans; Nienke van Engelen; Cornelia Eckert; Christian Peter Kratz

doi:10.1038/s41375-021-01163-y

Clinical and genetic characteristics of children with acute lymphoblastic leukemia and Li-Fraumeni syndrome

Leukemia. 2021 May;35(5):1475-1479. doi: 10.1038/s41375-021-01163-y. Epub 2021 Feb 12.

Authors

Greta Winter¹, Renate Kirschner-Schwabe^{2

3}, Stefanie Groeneveld-Krentz², Gabriele Escherich⁴, Anja Möricke⁵, Arend von Stackelberg², Martin Stanulla¹, Simon Bailey⁶, Lisa Richter⁷, Doris Steinemann⁸, Tim Ripperger⁸, Adela Escudero⁹, Roula Farah¹⁰, Olli Lohi¹¹, Karin Wadt¹², Marjolijn Jongmans^{13

14}, Nienke van Engelen¹⁴, Cornelia Eckert^{2

3}, Christian Peter Kratz¹⁵

Affiliations

¹ Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
² Department of Pediatric Oncology and Hematology, Charité-University Medical Center Berlin, Berlin, Germany.
³ German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁴ Pediatric Hematology and Oncology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
⁵ Department of Pediatrics, Christian-Albrechts-University Kiel, Kiel, Germany.
⁶ Great North Children's Hospital and Newcastle University, Newcastle upon Tyne, UK.
⁷ Pediatric Hematology and Oncology, University Hospital Essen, Essen, Germany.
⁸ Department of Human Genetics, Hannover Medical School, Hannover, Germany.
⁹ Translational Research in Pediatric Oncology, Hematopoietic Stem Cell Transplantation and Cell Therapy, Institute of Medical and Molecular Genetics, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
¹⁰ Department of Pediatrics, Lebanese American University Medical Center-Rizk Hospital, Beirut, Lebanon.
¹¹ Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland.
¹² Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
¹³ Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
¹⁴ Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
¹⁵ Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany. kratz.christian@mh-hannover.de.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Child, Preschool
Female
Genetic Predisposition to Disease / genetics*
Germ-Line Mutation / genetics
Humans
Li-Fraumeni Syndrome / genetics*
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*