Microbial keratitis associated with contaminated ocular medications

Am J Ophthalmol. 1988 Apr 15;105(4):361-5. doi: 10.1016/0002-9394(88)90298-x.


We studied seven cases of severe gram-negative microbial keratitis associated with the use of contaminated topical ocular medications. Five cases involved Pseudomonas aeruginosa, one involved Serratia marcescens, and one involved Proteus mirabilis. In each case the same organism was cultured from corneal scrapings and from the medication. Either prednisolone acetate (one case) or timolol maleate (seven cases) was implicated in all instances.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Topical
  • Aged
  • Aged, 80 and over
  • Corneal Ulcer / etiology
  • Corneal Ulcer / pathology
  • Drug Contamination*
  • Female
  • Humans
  • Keratitis / complications
  • Keratitis / etiology*
  • Male
  • Prednisolone / analogs & derivatives*
  • Pseudomonas Infections*
  • Timolol*


  • Timolol
  • prednisolone acetate
  • Prednisolone