Hepatopancreatoduodenectomy with simultaneous resection of the portal vein and hepatic artery for locally advanced cholangiocarcinoma: Short- and long-term outcomes of superextended surgery

J Hepatobiliary Pancreat Sci. 2021 Apr;28(4):376-386. doi: 10.1002/jhbp.914. Epub 2021 Mar 12.


Background: Only a few authors have reported negative results for hepatopancreatoduodenectomy (HPD) with simultaneous resection of the portal vein and hepatic artery in a limited number of patients. The aim of the current study was to outline our experience with this superextended surgery and to discuss its clinical value.

Methods: Medical records of consecutive patients who underwent resection of perihilar cholangiocarcinoma between 2007 and 2020 were retrospectively reviewed.

Results: During the study interval, 650 patients with perihilar cholangiocarcinoma underwent resection. The superextended surgery was performed in only nine (1.4%) patients. Left or right trisectionectomy was primarily performed. For portal vein reconstruction, external iliac vein graft was required in seven patients. For hepatic artery reconstruction, rotating left gastric artery was often used. The median operative time was 870 minutes and blood loss was 2,598 mL. Postoperatively, pancreatic fistula and liver failure occurred in all patients, followed by intraabdominal abscess (n = 8), and bacteremia (n = 4). One patient died on day 86 due to multiple organ failure. Two patients survived for more than 7 years.

Conclusions: HPD with simultaneous resection of the portal vein and hepatic artery is demanding but worth performing as the last option, with careful patient selection in experienced centers.

Keywords: cholangiocarcinoma; hepatic artery resection; hepatopancreatoduodenectomy; portal vein resection.

MeSH terms

  • Bile Duct Neoplasms* / diagnostic imaging
  • Bile Duct Neoplasms* / surgery
  • Bile Ducts, Intrahepatic
  • Cholangiocarcinoma* / diagnostic imaging
  • Cholangiocarcinoma* / surgery
  • Hepatectomy
  • Hepatic Artery / diagnostic imaging
  • Hepatic Artery / surgery
  • Humans
  • Portal Vein / diagnostic imaging
  • Portal Vein / surgery
  • Retrospective Studies