Some adverse reactions to allopurinol may be mediated by lymphocyte reactivity to oxypurinol

Arthritis Rheum. 1988 Mar;31(3):436-40. doi: 10.1002/art.1780310318.


Six of 9 patients with previously documented adverse reactions to allopurinol exhibited transformation of their peripheral blood lymphocytes when these were exposed in vitro to the allopurinol metabolite, oxypurinol. In 2 of these subjects, intradermal skin challenge was positive at 48 hours with either allopurinol or oxypurinol. The evidence presented suggests that some adverse reactions to allopurinol represent delayed-type hypersensitivity to oxypurinol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allopurinol / adverse effects*
  • Humans
  • Lymphocyte Activation
  • Lymphocytes / immunology*
  • Oxypurinol / immunology*
  • Pyrimidines / immunology*
  • Skin Tests


  • Pyrimidines
  • Allopurinol
  • Oxypurinol