[Morphofunctional changes in the pancreas in response to dalargin under normal conditions and in experimental pancreatitis]

Biull Eksp Biol Med. 1988 Apr;105(4):445-7.
[Article in Russian]

Abstract

The influence of dalargin on pancreatic secretion stimulated by different agents has been studied in experiments on dogs. Intravenous infusion of dalargin (50 micrograms/kg/hour) induced intensive inhibition of both secretion volume and protease content. The data have been obtained on a positive influence of dalargin on acute experimental pancreatitis in rats. A reduction in synthetic processes in acinar cells, reestablishment of microcirculation in the affected zones and the absence of disturbances in the marginal zones of the pancreas have been observed.

MeSH terms

  • Acute Disease
  • Animals
  • Dogs
  • Enkephalin, Leucine / analogs & derivatives*
  • Enkephalin, Leucine / pharmacology
  • Enkephalin, Leucine / therapeutic use
  • Enkephalin, Leucine-2-Alanine* / analogs & derivatives*
  • Male
  • Pancreas / drug effects*
  • Pancreas / metabolism
  • Pancreatic Juice / metabolism
  • Pancreatitis / drug therapy*
  • Rats

Substances

  • Enkephalin, Leucine
  • Enkephalin, Leucine-2-Alanine
  • enkephalin-Leu, Ala(2)-Arg(6)-