[Genetic aspects of the immunomodulating action of interferon]

Biull Eksp Biol Med. 1988 Apr;105(4):459-61.
[Article in Russian]


The data of the study of alpha/beta interferon (IFN) effect in mice of different genotype were presented. CBA mice of H-2k genotype, C57B1/6 mice of H-2b genotype and their hybrid (CBA X C57B1/6) F1 have been used in the experiments. IFN has been injected intraperitoneally in a dose of 100-5000 U/mouse in combination with antigenic stimulation. It was shown that IFN enhanced stem cells migration from bone marrow in CBA, but not in (CBA X C57B1/6)F1 mice. At the same time the splenocytes from CBA mice were more sensitive to inhibition by IFN than splenocytes from C57B1/6 mice. This was found in antibody and immune rosette-formation tests. The effect of IFN on the immune system cells is probably predetermined by the individual genetic characteristics of a mouse strain.

Publication types

  • English Abstract

MeSH terms

  • Adjuvants, Immunologic / genetics*
  • Adjuvants, Immunologic / immunology
  • Animals
  • Antibody-Producing Cells / drug effects
  • Cell Movement / drug effects
  • Hematopoietic Stem Cells / drug effects
  • Hybridization, Genetic
  • Interferon Type I / genetics*
  • Interferon Type I / immunology
  • Mice
  • Mice, Inbred C57BL / genetics
  • Mice, Inbred CBA / genetics
  • Rosette Formation


  • Adjuvants, Immunologic
  • Interferon Type I