Classic and overlapping Miller-Fisher syndrome: clinical and electrophysiological features in Mexican adults

Neurol Sci. 2021 Oct;42(10):4225-4229. doi: 10.1007/s10072-020-05029-6. Epub 2021 Feb 16.


Classic and overlapping Miller-Fisher syndrome (MFS) have divergent clinical courses. Few studies have addressed the electrophysiological evaluation of MFS patients, most of them carried out in Asia. This work describes and compares their clinical and neurophysiological characteristics. From a Guillain-Barré syndrome (GBS) patient cohort, we made a selection of twenty MFS cases. We defined classic and overlapping MFS, as stated by Wakerley et al. (Nat Rev Neurol 10(9):537-544, 2014). We describe and compare clinical, biochemical, and electrodiagnostic parameters between groups. Seventy-five percent were men, mean age was 42.2 ± 13.6 years, and 45% had a Hughes score ≥ 3. MFS/GBS was the most frequent clinical subtype with 50%. Almost one-third had unaltered electrophysiological studies. Comparative analysis between groups showed statistically significant differences in length of stay, dysautonomia presence, and treatment type. Kaplan-Meier survival analysis showed that 100% of the patients had an independent walk at 3 months. This study reports Mexican MFS patient's characteristics and represents the most extensive case series in Latin America. We observed a high proportion of overlapping syndromes, a good recovery profile, and no significant severe complications.

Keywords: Clinical; Electrophysiological; Guillain-Barré syndrome; Miller-Fisher syndrome; Overlap syndrome.

MeSH terms

  • Adult
  • Autoimmune Diseases*
  • Cohort Studies
  • Guillain-Barre Syndrome*
  • Humans
  • Male
  • Middle Aged
  • Miller Fisher Syndrome* / diagnosis
  • Miller Fisher Syndrome* / epidemiology
  • Miller Fisher Syndrome* / therapy
  • Walking