Increase of tyrosinase activity at the wound site in zebrafish imaged by a new fluorescent probe

Ziyin Chai; Jizhen Shang; Wen Shi; Xiaohua Li; Huimin Ma

doi:10.1039/d0cc08134e

Increase of tyrosinase activity at the wound site in zebrafish imaged by a new fluorescent probe

Chem Commun (Camb). 2021 Mar 16;57(22):2764-2767. doi: 10.1039/d0cc08134e.

Authors

Ziyin Chai¹, Jizhen Shang², Wen Shi¹, Xiaohua Li², Huimin Ma¹

Affiliations

¹ Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. shiwen@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, China.
² Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. shiwen@iccas.ac.cn.

PMID: 33595549
DOI: 10.1039/d0cc08134e

Abstract

Tyrosinase plays a pivotal role in the hyperpigmentation of wounds. Here, we develop a new fluorescent probe and with it, we reveal an increase of tyrosinase activity at the wound site in zebrafish.

MeSH terms

Animals
Fluorescent Dyes / chemistry*
HeLa Cells
Humans
Monophenol Monooxygenase / metabolism*
Oxidation-Reduction
Spectrum Analysis / methods
Wounds and Injuries / enzymology*
Zebrafish

Substances

Fluorescent Dyes
Monophenol Monooxygenase