Vitamin D3 to Treat COVID-19: Different Disease, Same Answer

doi:10.1001/jama.2020.26850

Comment

. 2021 Mar 16;325(11):1047-1048.

doi: 10.1001/jama.2020.26850.

Vitamin D3 to Treat COVID-19: Different Disease, Same Answer

David E Leaf¹, Adit A Ginde²

Affiliations

¹ Division of Renal Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
² Department of Emergency Medicine, University of Colorado School of Medicine, Aurora.

PMID: 33595641
PMCID: PMC8412177
DOI: 10.1001/jama.2020.26850

Comment

Vitamin D3 to Treat COVID-19: Different Disease, Same Answer

David E Leaf et al. JAMA. 2021.

. 2021 Mar 16;325(11):1047-1048.

doi: 10.1001/jama.2020.26850.

Authors

David E Leaf¹, Adit A Ginde²

Affiliations

¹ Division of Renal Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
² Department of Emergency Medicine, University of Colorado School of Medicine, Aurora.

PMID: 33595641
PMCID: PMC8412177
DOI: 10.1001/jama.2020.26850

No abstract available

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Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.
Murai IH, Fernandes AL, Sales LP, Pinto AJ, Goessler KF, Duran CSC, Silva CBR, Franco AS, Macedo MB, Dalmolin HHH, Baggio J, Balbi GGM, Reis BZ, Antonangelo L, Caparbo VF, Gualano B, Pereira RMR. Murai IH, et al. JAMA. 2021 Mar 16;325(11):1053-1060. doi: 10.1001/jama.2020.26848. JAMA. 2021. PMID: 33595634 Free PMC article. Clinical Trial.

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References

1. Liu PT, Stenger S, Li H, et al.Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311(5768): 1770–1773. doi:10.1126/science.1123933 - DOI - PubMed
1. Kong J, Zhu X, Shi Y, et al.VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system. Mol Endocrinol. 2013;27 (12):2116–2125. doi:10.1210/me.2013-1146 - DOI - PMC - PubMed
1. Zhang YP, Wan YD, Sun TW, Kan QC, Wang LX. Association between vitamin D deficiency and mortality in critically ill adult patients: a meta-analysis of cohort studies. Crit Care. 2014;18 (6):684. doi:10.1186/s13054-014-0684-9 - DOI - PMC - PubMed
1. Ali N Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 2020;13(10):1373–1380. doi:10.1016/j.jiph.2020.06.021 - DOI - PMC - PubMed
1. Amrein K, Schnedl C, Holl A, et al.Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA. 2014; 312(15):1520–1530. doi:10.1001/jama.2014.13204 - DOI - PubMed

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[1] Liu PT, Stenger S, Li H, et al.Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311(5768): 1770–1773. doi:10.1126/science.1123933 - DOI - PubMed

[2] Liu PT, Stenger S, Li H, et al.Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311(5768): 1770–1773. doi:10.1126/science.1123933 - DOI - PubMed

[3] Kong J, Zhu X, Shi Y, et al.VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system. Mol Endocrinol. 2013;27 (12):2116–2125. doi:10.1210/me.2013-1146 - DOI - PMC - PubMed

[4] Kong J, Zhu X, Shi Y, et al.VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system. Mol Endocrinol. 2013;27 (12):2116–2125. doi:10.1210/me.2013-1146 - DOI - PMC - PubMed

[5] Zhang YP, Wan YD, Sun TW, Kan QC, Wang LX. Association between vitamin D deficiency and mortality in critically ill adult patients: a meta-analysis of cohort studies. Crit Care. 2014;18 (6):684. doi:10.1186/s13054-014-0684-9 - DOI - PMC - PubMed

[6] Zhang YP, Wan YD, Sun TW, Kan QC, Wang LX. Association between vitamin D deficiency and mortality in critically ill adult patients: a meta-analysis of cohort studies. Crit Care. 2014;18 (6):684. doi:10.1186/s13054-014-0684-9 - DOI - PMC - PubMed

[7] Ali N Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 2020;13(10):1373–1380. doi:10.1016/j.jiph.2020.06.021 - DOI - PMC - PubMed

[8] Ali N Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 2020;13(10):1373–1380. doi:10.1016/j.jiph.2020.06.021 - DOI - PMC - PubMed

[9] Amrein K, Schnedl C, Holl A, et al.Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA. 2014; 312(15):1520–1530. doi:10.1001/jama.2014.13204 - DOI - PubMed

[10] Amrein K, Schnedl C, Holl A, et al.Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA. 2014; 312(15):1520–1530. doi:10.1001/jama.2014.13204 - DOI - PubMed

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Vitamin D3 to Treat COVID-19: Different Disease, Same Answer

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