Delayed kidney transplantation in combined liver-kidney transplantation

Curr Opin Organ Transplant. 2021 Apr 1;26(2):153-159. doi: 10.1097/MOT.0000000000000858.


Purpose of review: To review the impact of delayed kidney transplantation approach in combined (simultaneous) liver-kidney transplantation (CLKT).

Recent findings: CLKT offers a life-saving procedure for patients with both end-stage liver disease and chronic kidney disease or prolonged acute kidney injury. It is the most common multiorgan transplant procedure in the US accounting for 9-10% of all liver transplants performed. The number of CLKT has also been increasing in other countries with a better understanding of hepato-renal syndrome. US is the only country which implemented a national allocation policy for CLKT in 2017. Due to the different physiological needs of liver and kidney allografts immediately after transplantation, delayed kidney transplantation approach in CLKT has been introduced for the first time by the Indiana Group, naming it as 'the Indiana Approach'. Over the years, many other groups in the US and in Europe published better outcomes in CLKT using the delayed kidney transplantation approach with the support of hypothermic machine perfusion.

Summary: Several groups have shown that delayed kidney transplantation in CLKT is a safe procedure with better outcomes in graft(s) and patient survival.

Publication types

  • Review

MeSH terms

  • Graft Survival
  • Humans
  • Kidney
  • Kidney Transplantation* / adverse effects
  • Liver
  • Liver Transplantation*
  • Treatment Outcome