Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1374-1389. doi: 10.1161/ATVBAHA.121.315941. Epub 2021 Feb 18.

Abstract

[Figure: see text].

Keywords: cadherins; diabetic retinopathy; permeability; syndecans; vascular endothelial growth factor A.

Publication types

  • Research Support, Non-U.S. Gov't
  • Video-Audio Media

MeSH terms

  • Animals
  • Antigens, CD / metabolism*
  • Cadherins / metabolism*
  • Capillary Permeability
  • Choroidal Neovascularization / genetics
  • Choroidal Neovascularization / metabolism*
  • Choroidal Neovascularization / pathology
  • Disease Models, Animal
  • Endothelial Cells / drug effects
  • Endothelial Cells / metabolism
  • Female
  • Humans
  • Macular Degeneration / genetics
  • Macular Degeneration / metabolism*
  • Macular Degeneration / pathology
  • Male
  • Melanoma, Experimental / genetics
  • Melanoma, Experimental / metabolism*
  • Melanoma, Experimental / pathology
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Neovascularization, Pathologic*
  • Neovascularization, Physiologic / drug effects*
  • Retinal Neovascularization / genetics
  • Retinal Neovascularization / metabolism*
  • Retinal Neovascularization / pathology
  • Retinal Vessels / drug effects*
  • Retinal Vessels / metabolism*
  • Retinal Vessels / pathology*
  • Signal Transduction
  • Skin Neoplasms / genetics
  • Skin Neoplasms / metabolism*
  • Skin Neoplasms / pathology
  • Syndecan-4 / genetics
  • Syndecan-4 / metabolism*
  • Vascular Endothelial Growth Factor A / pharmacology*
  • Vascular Endothelial Growth Factor Receptor-2 / agonists
  • Vascular Endothelial Growth Factor Receptor-2 / metabolism

Substances

  • Antigens, CD
  • Cadherins
  • Sdc4 protein, mouse
  • Syndecan-4
  • Vascular Endothelial Growth Factor A
  • cadherin 5
  • Kdr protein, mouse
  • Vascular Endothelial Growth Factor Receptor-2