Evaluation of a Cetylpyridinium Chloride-, Dipotassium Glycyrrhizinate-, and Tranexamic Acid-based Mouthwash after Implant Placement: A Double-blind Randomised Clinical Trial

Oral Health Prev Dent. 2021 Jan 7;19(1):157-167. doi: 10.3290/j.ohpd.b966793.


Purpose: To evaluate the positive effects of a CPC-, GK2-, and TXA-based (CPC/GK2/TXA) mouthwash after implant placement.

Materials and methods: Twenty patients (n = 20) who underwent posterior implant-placement surgery were randomly and evenly allocated to the study or the placebo group. After the mouthwash was used 3x/day for 7 to 10 days postoperatively, sutures were analysed by counting the colony-forming units (CFU) for total aerobes, total G [-] anaerobes, total enterobacteria and total H. influenzae, followed by Real-Time PCR of bacterial-specific DNAs of A. actinomycetemcomitans, P. gingivalis, T. forsythia, T. denticola, P. intermedia, P. micra, F. nucleatum, C. rectus, and E. corrodens. In vitro resistance of P. gingivalis, S. aureus, and P. aeruginosa was analysed. The compatibility of the mouthwash with Straumann SLA implant surfaces was evaluated by scanning electron microscopy (SEM).

Results: Sixteen patients (n = 16) completed the trial. A statistically significantly greater number of CFU was found in the placebo group for almost all species, especially for total G [-] anaerobes. No statistically significant in vitro resistance was found for P. gingivalis, S. aureus, and P. aeruginosa. SEM revealed no surface alteration after exposure to the mouthwash.

Conclusion: The use of a CPC/GK2/TXA mouthwash inhibited propagation of the bacteria extracted from the post-surgical sutures after implant placement.

Keywords: antibacterial agents; biofilms; implantology; periodontology; microbiology.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Cetylpyridinium*
  • Glycyrrhizic Acid
  • Humans
  • Mouthwashes
  • Porphyromonas gingivalis
  • Staphylococcus aureus
  • Tranexamic Acid*


  • Mouthwashes
  • Glycyrrhizic Acid
  • Tranexamic Acid
  • Cetylpyridinium