Oxygen-Releasing Biomaterials: Current Challenges and Future Applications

Trends Biotechnol. 2021 Nov;39(11):1144-1159. doi: 10.1016/j.tibtech.2021.01.007. Epub 2021 Feb 16.


Oxygen is essential for the survival, function, and fate of mammalian cells. Oxygen tension controls cellular behaviour via metabolic programming, which in turn controls tissue regeneration, stem cell differentiation, drug metabolism, and numerous pathologies. Thus, oxygen-releasing biomaterials represent a novel and unique strategy to gain control over a variety of in vivo processes. Consequently, numerous oxygen-generating or carrying materials have been developed in recent years, which offer innovative solutions in the field of drug efficiency, regenerative medicine, and engineered living systems. In this review, we discuss the latest trends, highlight current challenges and solutions, and provide a future perspective on the field of oxygen-releasing materials.

Keywords: biomaterials; hypoxia; metabolism; oxygen generation; sustained release.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biocompatible Materials
  • Cell Differentiation
  • Mammals
  • Oxygen* / metabolism
  • Regenerative Medicine
  • Tissue Engineering*


  • Biocompatible Materials
  • Oxygen