Non-human primates and Leishmania immunity

Cytokine X. 2020 Oct 12;2(4):100038. doi: 10.1016/j.cytox.2020.100038. eCollection 2020 Dec.


In the context of infectious diseases, non-human primates (NHP) provide the best animal models of human diseases due to the close phylogenetic relationship and the similar physiology and anatomical systems. Herein, we summarized the contribution of NHP models for understanding the immunity to leishmaniases, which are a group of diseases caused by infection with protozoan parasites of the genus Leishmania and classified as one of the neglected tropical diseases.

Keywords: CXCR5; Cytokines; Immunity; Leishmania; Monkeys; T cells; Tfh.