Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil

Emerg Infect Dis. 2021 May;27(5):1522-1524. doi: 10.3201/eid2705.210191. Epub 2021 Feb 19.


Uncertainty remains about how long the protective immune responses against severe acute respiratory syndrome coronavirus 2 persists, and suspected reinfection in recovered patients has been reported. We describe a case of reinfection from distinct virus lineages in Brazil harboring the E484K mutation, a variant associated with escape from neutralizing antibodies.

Keywords: Brazil; COVID-19; E484K spike mutation; SARS-CoV-2; coronavirus disease; genomic surveillance; reinfection; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Neutralizing
  • Brazil
  • COVID-19*
  • Genomics
  • Humans
  • Mutation
  • Reinfection
  • SARS-CoV-2*
  • Spike Glycoprotein, Coronavirus / genetics


  • Antibodies, Neutralizing
  • Spike Glycoprotein, Coronavirus