"Iron"ing out hemophagocytosis through PIEZO1

Cell. 2021 Feb 18;184(4):856-858. doi: 10.1016/j.cell.2021.01.038.


In this issue of Cell, Ma et al. reveal a mechanistic role for PIEZO1 in iron homeostasis through molecular genetic mouse studies. They also demonstrate implications for human iron overload and deficiency syndromes, susceptibility to malarial infection, and red blood cell turnover in persons of African ancestries.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Erythrocytes
  • Homeostasis
  • Humans
  • Ion Channels / genetics
  • Iron*
  • Malaria*
  • Mice


  • Ion Channels
  • PIEZO1 protein, human
  • Piezo1 protein, mouse
  • Iron