Statin-induced autoimmune myopathy: a case report

Eur J Hosp Pharm. 2021 Mar;28(2):115-117. doi: 10.1136/ejhpharm-2019-002102. Epub 2019 Nov 7.


Statins are widely used in the treatment of hypercholesterolemia. Muscle weakness and elevated creatine kinase (CK) are frequent side effects of statins with an incidence of about 15%. Statin-associated myopathy is more common in people who receive multiple drugs, the elderly or women but the mechanism underlying it is still unclear. These symptoms generally improve after drug discontinuation. However, there is a type of autoimmune mediated myopathy characterised by the persistence of muscle weakness and CK elevation after stopping statins. Herein, we discuss a case of autoimmune myopathy associated with statin exposure and responsive to immunossupresive drugs. The increased use of statins in recent years raises the importance of acquaintance with this disease in clinical practice.

Keywords: adverse effect; anti-HMGCR antibodies; immune-mediated necrotising myopathy; myopathy; statin.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Autoantibodies / adverse effects
  • Autoimmune Diseases* / chemically induced
  • Autoimmune Diseases* / diagnosis
  • Autoimmune Diseases* / drug therapy
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors* / adverse effects
  • Muscular Diseases* / chemically induced
  • Muscular Diseases* / diagnosis


  • Autoantibodies
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors