Abstract
The interactive effects of the coadministration of steady-state cimetidine and single-dose pentopril, an angiotensin converting enzyme inhibitor, on the pharmacokinetic disposition of each other were studied in humans. Cimetidine reduced the clearance of pentopril by 11 to 14%. This reduction in clearance was shown to be caused by a reduction in liver blood flow probably mediated through H2 receptor blockade. Meanwhile pentopril induced the oral clearance of cimetidine by 21%, presumably by a reduction in the bioavailable fraction of cimetidine. The mechanism of this interaction is unknown.
MeSH terms
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Administration, Oral
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Adult
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Angiotensin-Converting Enzyme Inhibitors / administration & dosage
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Angiotensin-Converting Enzyme Inhibitors / pharmacokinetics*
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Animals
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Cimetidine / administration & dosage
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Cimetidine / metabolism
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Cimetidine / pharmacokinetics*
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Drug Interactions
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Drug Therapy, Combination
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Humans
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Indoles / administration & dosage
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Indoles / metabolism
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Indoles / pharmacokinetics*
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Liver / blood supply*
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Liver / drug effects
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Liver / metabolism
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Male
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Random Allocation
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Rats
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Rats, Inbred Strains
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Regional Blood Flow / drug effects
Substances
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Angiotensin-Converting Enzyme Inhibitors
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Indoles
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Cimetidine
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CGS 13945