Biology of Radiation-Induced Lung Injury

Semin Radiat Oncol. 2021 Apr;31(2):155-161. doi: 10.1016/j.semradonc.2020.11.006.

Abstract

Radiation-induced lung injury encompasses radiation-induced pneumonitis, inflammation of the lung which may manifest as a dose-limiting acute or subacute toxicity, and radiation-induced lung fibrosis, a late effect of lung exposure to radiation. This review aims to highlight developments in molecular radiation biology of radiation-induced lung injury and their implications in clinical practice.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Humans
  • Lung
  • Lung Injury* / etiology
  • Lung Injury* / pathology
  • Pulmonary Fibrosis* / etiology
  • Pulmonary Fibrosis* / pathology
  • Radiation Pneumonitis* / etiology
  • Radiobiology