Epilepsy treatment outcomes in the referral hospitals of northeast Ethiopia

Abstract

Background: Globally, more than half of the epileptic patients have uncontrolled seizures despite treatment with the appropriate antiepileptic drugs. However, the problem has been remained under-reported especially in developing countries. Therefore, this study was designed to assess the treatment outcomes of epileptic patients in the referral hospitals of the Amhara region.

Methods: An institutional-based cross-sectional study was conducted among 420 epileptic patients in the referral hospitals of Amhara region. The study participants were selected by a systematic random sampling method using the patient registration logbook as a sampling frame. An interviewer-administered questionnaire and abstraction checklist were used to collect data. The data was entered into Epi-Data software version 3.1 and analyzed using the Statistical Package for Social Science) version 24.0. The Descriptive statistics were done and presented using the descriptive summaries and frequency tables. Bivariate and Multivariate Binary Logistic Regression Models with a Backward Elimination Method were done to identify the factors associated with the treatment outcome of epilepsy. The odds ratio with a 95 % confidence interval was used to determine the significance level of association.

Result: In this study, the magnitude of uncontrolled seizure was 44 % (95 % CI: 39%-48.6%). Being male [AOR = 0.39: 95 % CI 0.25,0.62], high medication necessity beliefs [AOR = 0.34: 95 %CI 0.2,0.57], positive medication beliefs [AOR = 0.23: 95 % CI: 0.13-0.4], and good medication adherence [AOR = 0.21: 95 % CI: 0.1-0.46] were the preventive factors of uncontrolled seizure. In contrast, the presence of co-morbidities [AOR = 2.22, 95 %CI:1.38-3.57] and poor social support [AOR = 1.7: 95 %CI:1.07-2.69] were a risk factors of uncontrolled seizures.

Conclusion: Uncontrolled seizure was found to be higher than the expected seizure frequency, which is preferably zero after one year of treatment. The clinical and treatment related factors were the factors associated with uncontrolled seizure. Emphasis should be given to the treatment strategies of epileptic patients. The health extension packages should integrate community-based counseling to enhance social support and early detection of comorbidities, increase medication adherence, and medication belief among epileptic patients.

Keywords: Amhara region; Controlled seizure; Epilepsy treatment outcome; Uncontrolled seizure.