Granulocyte and Monocyte Adsorptive Apheresis for Ulcerative Colitis in a Patient with Low Bone Mineral Density Due to Fanconi-Bickel Syndrome

Intern Med. 2021 Aug 1;60(15):2413-2417. doi: 10.2169/internalmedicine.6707-20. Epub 2021 Feb 22.


Systemic steroid is required for the exacerbation of ulcerative colitis (UC), although its administration should be avoided in patients with a low bone mineral density (BMD) exacerbated by side effects of steroids. We herein report the successful induction of remission in an UC case with a low BMD due to Fanconi-Bickel syndrome-or glycogen storage disease type XI-using granulocyte and monocyte adsorptive apheresis (GMA). For a 43-year-old woman with a BMD of 50% the young adult mean, GMA was performed 2 times a week for a total of 10 times. GMA might be a steroid-free treatment option for UC patients with a low BMD.

Keywords: Fanconi-Bickel Syndrome; bone density; granulocyte and monocyte adsorptive apheresis; ulcerative colitis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood Component Removal*
  • Bone Diseases, Metabolic*
  • Colitis, Ulcerative* / complications
  • Colitis, Ulcerative* / therapy
  • Fanconi Syndrome*
  • Female
  • Granulocytes
  • Humans
  • Leukapheresis
  • Monocytes
  • Remission Induction
  • Treatment Outcome