Growth and development of infants with end-stage renal disease receiving long-term peritoneal dialysis

J Pediatr. 1988 May;112(5):714-9. doi: 10.1016/s0022-3476(88)80687-5.

Abstract

The growth and development of four infants with end-stage renal disease receiving long-term peritoneal dialysis was studied during the first year of life. In each patient, dialysis was begun before 4 weeks of age. A nutritional regimen was designed to attain a daily weight gain appropriate for height age while minimizing the blood urea nitrogen level. A neurodevelopmental evaluation of gross and fine motor, cognitive, language, and psychosocial skills was performed at least every 3 months. At age 1 year, the mean height standard deviation score (SDS) was -1.33 +/- 0.2. Weight for height was greater than 95th percentile in one patient and normal in three. Mean caloric and protein intake were 105 +/- 20 kcal/kg/d (11.4 +/- 2.7 kcal/cm/d) and 2.7 g/kg/d (0.30 +/- 0.11 g/cm/d), respectively. Mean blood urea nitrogen was 53.6 +/- 17.8 mg/dL. Developmentally, three of the patients were functioning in the normal range and one was mildly retarded. However, gross motor skills were delayed in all patients. Although infants with end-stage renal disease are usually severely growth retarded and developmentally delayed, our observations suggest that early nutritional intervention and dialysis can yield improved results.

MeSH terms

  • Blood Urea Nitrogen
  • Body Height
  • Child Development
  • Dietary Proteins / administration & dosage
  • Energy Intake
  • Humans
  • Infant, Newborn
  • Kidney Failure, Chronic / psychology
  • Kidney Failure, Chronic / therapy*
  • Male
  • Motor Skills
  • Nutritional Physiological Phenomena
  • Peritoneal Dialysis*

Substances

  • Dietary Proteins